Caverject 20 Micrograms Powder For Solution For Injection

The patient should be instructed that, if the needle is bent, it must not be used; caverjett should also not attempt to straighten a bent needle. Alprostadil 20mcg, 40mcg; per vial; lyophilized pwd for intracavernous inj after reconstitution; contains benzyl alcohol. Caverject is administered by caverejt intracavernous injection. Company contact details Pfizer Limited. The effects of combinations of alprostadil with other treatments caverjet erectile dysfunction e. If you think there has been an overdose, call your poison control center or get medical care right away. Treatment Vaverjet initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary caverjet spinal cord injury is 1. Find out more here. The remainder of caverjet dose is excreted in the faeces. Alprostadil should not be used in patients who have a known hypersensitivity to alprostadil or to any of the excipients listed in section 6, caverjet. Continue typing to refine. Following intracavernous injection of 20 cavrejet of alprostadil, mean caverjte levels of alprostadil at 30 and 60 minutes after injection are not significantly greater than baseline levels of endogenous PGE 1. Individuals who use alprostadil should be counselled about the protective measures that are necessary cacerjet guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus HIV. If still unsuccessful, intracavernous injection of alpha-adrenergic medication is recommended. Caverjet minimize the risk, select the lowest effective dose. Caverject 20 micrograms powder for solution for injection. The caverjet should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. The potential for abuse of alprostadil should be considered in patients with a history of psychiatric disorder or addiction.

Date of revision of the text. Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular caverjet, Vein disorder. The lowest effective dose should be used. If there is a response, there should be at least a 1-day interval before the next dose caverjet given. This may detumesce the penis. Alprostadil is present in various mammalian tissues and fluids. Penile pain, prolonged erection, penile fibrosis, inj site hematoma or ecchymosis, penis caverjet, penile rash or edema, other local effects, dizziness. The occurrence of fibrosis may increase with increased duration of use. Use lowest effective dose. Reconstituted solutions of alprostadil are intended for single use only, they should be used immediately and not stored. Alprostadil may caverjet the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. Treatment of erectile dysfunction. Subsequent incremental increases of micrograms should be given until an optimal dose is achieved. In the majority of cases, spontaneous detumescence occurred. Year Company Conditions Areas Names Caverject alprostadil The following drug information is obtained from various newswires, published medical journal articles, and medical conference presentations. Caverjet slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. If there is a response, there should be at least a 1-day interval before the next dose is given. Overdosage was not observed in clinical trials with alprostadil. Such agents should not be used in combination with Caverject due to the potential for caverjet prolonged erections. Show table of contents Hide table of contents 1. Premature and low-birth weight infants may be more likely to develop toxicity. Hence, any alprostadil entering the systemic circulation following intracavernosal injection is rapidly metabolized. The second dose should be 5 micrograms if there is a partial response, caverjet, caverjet 7. Alprostadil should not be used in patients caverjet have a known hypersensitivity to alprostadil or to any of the excipients listed in section 6.

Adjust volume to the required dose for injection. Inject into the dorso-lateral aspect caverjet the proximal third of penis, avoid visible veins; rotate inj side and site. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. It has a diverse pharmacologic profile, among which some of its more important effects are vasodilation, inhibition of platelet aggregation, inhibition of gastric secretion, and stimulation of intestinal and uterine smooth muscle. Patients should be instructed to report immediately to a physician, or if unavailable to seek caverjet medical assistance for any erection lasting for a prolonged time period, such as 4 hours. Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. Company contact details Pfizer Limited. Alprostadil may enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. Use of intracavernosal alprostadil offers no protection from the transmission of sexually transmitted diseases. The first injections of alprostadil must be done by medically trained personnel, caverjet. The most frequent adverse effect following an intracavernous injection was pain in the caverjet. To minimise the risk, select the lowest effective dose. Any alprostadil entering the systemic circulation from the corpus cavernosum will be rapidly metabolised. Carefully remove the inner protective cap from the needle. As an aid to aetiologic diagnosis.

If the duration is longer, caverjet, the dose should be reduced. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft caverjet or diarrhoea and rapid breathing. Injection site haematoma, Haematoma, Ecchymosis. This site uses cookies. Sign Up Log In Cancel. Sexual stimulation and intercourse can lead to cardiac and pulmonary events in patients with coronary heart disease, congestive heart failure or pulmonary disease. The potential for abuse of alprostadil should be considered in patients with a caverjet of psychiatric disorder or addiction. Caverject 20 micrograms powder for solution for injection. Caverject is indicated for the treatment faverjet erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. Caverjet and low-birth weight infants may be caverjet likely to develop toxicity. Each 1ml of reconstituted solution contains 8. Instructions for use To perform the reconstitution, attach the needle to the device by pressing the needle onto the tip of the device and turning clockwise caveret it stops. Caverjey adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class. Powder for solution for injection A white to off-white powder. Alprostadil should be used with caution in patients with cardiovascular and cerebrovascular risk factors. It is recommended that the dose administered produces a duration of the erection not exceeding one hour. Sympathomimetics may reduce the effect of alprostadil. General disorders and administration site conditions. The treatment of priapism prolonged erection should not be delayed more caverjet 6 hours. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. To email a medicine you must sign up and log in. If necessary, this may be followed by further caverjet of blood through the same butterfly needle. In the latter case, caverjet should be available to manage a hypertensive crisis.

Caverjet

Peripheral levels of the major circulating metabolite, oxo,dihydro-PGE 1increase to reach acverjet peak 30 minutes caverjet injection and return to pre-dose levels by 60 minutes after injection, caverjet. To czverjet the reconstitution, attach the needle to the device by pressing the needle onto the tip of the device and turning clockwise until it stops. If there is a response, there should be at least a 1-day interval before the next dose is given. Instructions for use To perform the reconstitution, attach the needle to the device by pressing the needle onto the tip of the device and turning clockwise until it stops. Alprostadil is present xaverjet various mammalian tissues and fluids. The cavetjet should be instructed that, if caveerjet needle is bent, it must not be used; they should also not attempt to caverjet a bent needle. Marketing authorisation holder 8. The adverse drug reactions are listed in order of decreasing medical seriousness within each caveruet category and system organ class. Caverject 20 micrograms powder for solution for injection. Powder and solvent for solution for injection Dual chamber glass cartridge containing a white lyophilised powder and diluent for reconstitution. Alprostadil should not be used in patients who have a known hypersensitivity to caverjet or to any of the excipients listed in section 6. Using aseptic technique, insert a gauge butterfly needle into the corpus cavernosum and aspirate ml of cavermet. High doses of alprostadil 0. The drug's most common side effect is penile pain, caverjet. There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. Do not start, stop, or change the caverjet of any drug without checking with your doctor. High doses caverjet alprostadil 0. Reconstituted solutions of Caverject Dual Chamber are intended for single use only. Premature and low-birth weight infants may be more caverjet to develop toxicity. Patients should be instructed to report to a physician any erection lasting for a prolonged time period, such as 4 hours or longer. As with all superfine needles, the caverjet of needle breakage exists. If the duration is longer, the dose should be reduced.

In most cases it disappeared spontaneously. Caverjet of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important, caverjet. Reproductive system and breast disorders. In the majority of cases, spontaneous detumescence caverjet. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. If there is no response to the administered dose, then the next higher dose may be given within 1 hour. Sympathomimetics may reduce the effect of alprostadil. Fit the 22 gauge needle to the syringe. Qualitative and quantitative composition 3. The patient should be instructed that, if the needle is bent, it must not caverjet used; they should also not attempt to straighten a bent needle. To bookmark a medicine you must sign up and log in. The minimum amount of benzyl alcohol at which toxicity may occur is not known. Last updated on eMC: A complete physical examination is important so that any underlying condition can be diagnosed and treated. Evaluate and treat underlying causes prior to initiating therapy.

Shelf life of the medicinal product as packaged for sale 36 months. Caverject Dual Chamber should not be used in men for caverjet sexual activity is inadvisable or contraindicated e. They should remove the needle from caverjet syringe, discard it, and attach a new, unused sterile needle to the syringe. Subsequent incremental increases of micrograms should be given until an optimal dose is achieved, caverjet. You may also report side effects at http: Qualitative and quantitative composition 3. Reconstituted solutions of alprostadil are intended for single caverjet only, they should be used immediately and not stored. It is recommended that the dose administered produces a duration of the erection not exceeding one hour. They should remove the needle from the syringe, discard it, and attach a new, unused sterile needle to the syringe. If necessary, caverjet, this may be followed by further aspiration of blood through the same butterfly needle. Use of intracavernosal alprostadil offers no protection from the transmission caverjet sexually transmitted diseases. This site uses cookies. The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. The first injections of alprostadil must be done by medically trained personnel. There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. Patients on caverjet such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. If the duration is longer, the dose should be reduced. The lowest effective dose should be used. The most frequent adverse effect following an intracavernous injection was caverjet in the penis. Caverject may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction. Following intracavernous injection of 20 micrograms of alprostadil, mean peripheral levels of alprostadil at 30 and 60 minutes after injection are not significantly caverjet than baseline levels of endogenous PGE 1. In some patients, injection of Caverject Dual Chamber can induce a small amount of bleeding at the site of injection.

The most frequent adverse reaction after intracavernosal injection of alprostadil is penile pain. Such agents should not be used in combination with alprostadil due to the potential for inducing prolonged erections. Powder for solution for injection A white to off-white powder. Initial therapy should be by penile aspiration. Pharmacokinetics in sub-populations Effect of renal or hepatic impairment: Careful patient instruction in proper handling and injection techniques may minimise the potential for needle breakage. To reconstitute Caverject using the prefilled diluent syringe: Subjects without evidence of neurological dysfunction: Overdosage was not observed in clinical trials with alprostadil. Sexual stimulation and intercourse can lead to cardiac and pulmonary events in patients with coronary heart disease, congestive heart failure or pulmonary disease. The following doses can be given using Caverject Dual Chamber: This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Alprostadil should not be used in men for whom sexual activity is inadvisable or contraindicated. Inject the 1 ml caverjef diluent into the vial, and shake to dissolve the powder entirely, caverjet. Alprostadil concentrations then returned to caverjet levels within 2 hours after injection. When reconstituted, each 1ml delivers a dose of 20 micrograms of alprostadil. Alprostadil caverjt be used with caverjet in patients with cardiovascular and cerebrovascular risk factors. Not known cannot be estimated from the available data. Date of first authorisation: Rash, Caverjet, Pruritus, Erythema.

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In some patients, injection of alprostadil can induce a small amount of bleeding at the site of injection. The caverjet that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. To view the changes to a medicine you must sign up and log caverjet. Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a caverjet swab. Alprostadil may enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors, caverjet. Careful patient instruction in proper handling and injection techniques may minimise the potential for needle breakage. Sodium For the full list of excipients, caverjet, see section 6. Caverject is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. Treatment The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Reconstituted solutions are intended for single use only, they should be used immediately and not stored. Alprostadil should be used with caution in patients who have experienced caverjet ischaemic attacks or those with unstable cardiovascular caverjet. Subsequent incremental increases of 5 - 10 micrograms should be given until an optimal dose is identified. If necessary, this may be followed caverjet further aspiration of blood through the same butterfly needle. Premature and low-birth weight infants may be more likely to develop toxicity. As an alternative metaraminol may be used, caverjet, but it should be noted that fatal hypertensive crises have been reported. In pigtail monkeys Macaca nemestrinaalprostadil increased cavernous arterial blood flow in vivo. Patients should be instructed to report to a physician any erection lasting for a prolonged time period, such as 4 hours or longer. Symptomatic treatment of any systemic symptoms would be appropriate. Caverjet the side of the penis that is injected and the site of injection must be alternated; prior to the injection, the injection site must be cleansed with an alcohol swab. There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. A few drops will appear at the needle tip. The occurrence of fibrosis caverjet increase with increased duration of use. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, Micturition urgency. Turn the end of the plunger rod clockwise to select the desired dose. Dual chamber glass cartridge containing a white lyophilised powder and diluent for reconstitution.

Invert the device twice in order to make sure the solution is evenly mixed. Alprostadil is present in various mammalian tissues and fluids. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Find out more here. For patients with erectile dysfunction of neurogenic origin requiring doses less than 2. The first injections of alprostadil must be done by medically trained personnel. Powder for solution for injection A white to off-white powder. Plasma concentrations of 13,dihydro-PGE 1 increased 7 fold, 20 minutes after injection. The second dose should be 5 micrograms if there is a partial response, and 7. It is recommended that patients are regularly monitored e. The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. Thirty percent of patients reported pain at least once. The treatment of priapism prolonged erection should not be delayed more than 6 hours. By continuing to browse the site you are agreeing to our policy on the use of cookies. The most frequent adverse reaction after intracavernosal injection of alprostadil is penile pain. This site uses cookies. Seventy men with a stable heterosexual partner entered the titration phase of this open-label, flexible-dose study. Treatment of priapism should not be delayed more than 6 hours please refer to Section 4.

Uses of Caverject:

The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. Caverject Dual Chamber may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction. There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. Therefore, a more consistent product delivery is produced when Bacteriostatic Water for Injection containing benzyl alcohol is used. Last updated on eMC: The lowest effective dose should be used. To reconstitute Caverject using the prefilled diluent syringe: Rash, Hyperhidrosis, Pruritus, Erythema. Excipients with known effect: Therefore, a more consistent product delivery is produced when Bacteriostatic Water for Injection containing benzyl alcohol is used. There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. A vacuum device involves placing a cylinder-like device and attached pump over the penis. If you think there has been an overdose, call your poison control center or get medical care right away. The syringe and any remaining solution should be properly discarded. In contrast to keto-PGE 1 and keto,dihydro-PGE 1 , which lack almost completely biological activity, 13,dihydro-PGE 1 has been shown to lower blood pressure and inhibit platelet aggregation. Patients should be instructed to report to a physician any erection lasting for a prolonged time period, such as 4 hours or longer. Sodium For the full list of excipients, see section 6. The dose of Caverject should be individualised for each patient by careful titration under supervision by a physician. Refer to our editorial policy for content sources and attributions. If still unsuccessful, intracavernous injection of alpha-adrenergic medication is recommended. Alprostadil would not be expected to have an influence on the ability to drive or operate machines. Premature and low-birth weight infants may be more likely to develop toxicity.

For the treatment of erectile dysfunction, alprostadil is administered by injection into the corpora cavernosa. Patients should be instructed to report immediately to a physician, or if unavailable to seek immediate medical assistance for any erection lasting for a prolonged time period, such as 4 hours. Alprostadil should not be used in patients who have a known hypersensitivity to alprostadil or to any of the excipients listed in section 6. As an aid to aetiologic diagnosis. If the duration is longer, the dose should be reduced. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap. Painful erection is more likely to occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. Enter medicine name or company Start typing to retrieve search suggestions. Marketing authorisation number s 9. Penile fibrosis, including angulation, cavernosal fibrosis, fibrotic nodules and Peyronie's disease may occur following the intracavernosal administration of Caverject Dual Chamber. Symptomatic treatment of any systemic symptoms would be appropriate. As an aid to aetiologic diagnosis. If self-administration is planned, the physician should make an assessment of the patient's skill and competence with the procedure. Peripheral levels of the major circulating metabolite, oxo,dihydro-PGE 1 , increase to reach a peak 30 minutes after injection and return to pre-dose levels by 60 minutes after injection. Qualitative and quantitative composition 3. To reconstitute Caverject using the prefilled diluent syringe: Fit the 22 gauge needle to the syringe. Enter medicine name or company Start typing to retrieve search suggestions. Peyronie's disease, Penis disorder, Erection increased. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. Alprostadil should not be used in men for whom sexual activity is inadvisable or contraindicated. All drugs may cause side effects. Treatment of erectile dysfunction. Overdosage was not observed in clinical trials with alprostadil. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Using aseptic technique, insert a gauge butterfly needle into the corpus cavernosum and aspirate ml of blood. Patients should be instructed to report immediately to a physician, or if unavailable to seek immediate medical assistance for any erection lasting for a prolonged caverjet period, such as 4 hours. The risk of benzyl alcohol caverjet depends on the quantity administered and the hepatic capacity to detoxify the chemical. Alprostadil 20mcg, 40mcg; per vial; lyophilized pwd for intracavernous inj after reconstitution; contains benzyl alcohol. Treatment of priapism should not be delayed more than 6 hours please refer to Section 4.

At the time of discharge from the clinic, the erection should have subsided entirely and the penis must be in a completely flaccid state. Premature and low-birth weight infants may be more likely to develop toxicity. Alprostadil should be used with caution in patients with cardiovascular and cerebrovascular risk factors. Inject into the dorso-lateral aspect in the proximal third of penis, avoid visible veins; rotate inj side and site. Each 1ml of reconstituted solution contains 8. A constriction band is then placed at the base of the penis to maintain erection. Reproductive System and Breast Disorders. If the duration is longer, the dose should be reduced. Although the usual contra-indication to intrapenile administration of a vasoconstrictor does not apply in the treatment of priapism, caution is advised when this option is exercised. Drugs used in erectile dysfunction ATC code: Following administration, any unused contents of the vial or syringe should be discarded. Caverject should be used with care in patients who have experienced transient ischaemic attacks or those with unstable cardiovascular disorders. Drugs used in erectile dysfunction ATC code: The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. It is self-injected into the penis shortly before sexual intercourse. The occurrence of fibrosis may increase with increased duration of use. In the latter case, facilities should be available to manage a hypertensive crisis. To bookmark a medicine you must sign up and log in. The potential caverjet abuse of alprostadil should be considered in patients with a history of psychiatric disorder or addiction. Company contact details Pfizer Limited. When reconstituted, each 1ml delivers a dose of 20 micrograms of alprostadil. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed caverjeet be mediated by inhibition caverjdt alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle.