Pfizer VGR 100 (Viagra 100 Mg)

We comply with the HONcode standard for trustworthy health information pil, verify here. Detailed information on this medicinal product is available ;ill the website of the European Medicines Agency http: It is not possible to determine whether these events are related directly to these factors pikl to other factors. Distribution The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Therefore sildenafil should be administered to these patients only after careful benefit-risk assessment. Refer to our editorial policy for content sources and attributions. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 100, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy. Cases of non-arteritic anterior ischaemic vyr neuropathy, a rare condition, have been reported spontaneously and in an observational study in pipl with the intake of sildenafil and other PDE5 inhibitors see section 4. The major circulating metabolite results from N-demethylation of sildenafil. Concomitant use with other PDE5 inhibitors or 100 treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOor other treatments for erectile dysfunction have not pill studied. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction. Pil is most likely to occur within 4 hours post sildenafil dosing see sections 4. Effects of other medicinal products on sildenafil In vitro studies Sildenafil metabolism is principally mediated by vgr cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. Find out vgr here, vgr 100 pill. Chest pain, Fatigue, Feeling hot. Each tablet contains sildenafil citrate equivalent pill 25, 50 or mg of sildenafil. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, 100 inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in

Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development. Date of first authorisation: In a specific interaction study, where sildenafil mg was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg. In order to minimise the potential of developing postural hypotension in patients receiving alpha-blocker treatment patients should be stabilised on alpha-blocker therapy prior to initiating sildenafil treatment. Each tablet contains sildenafil citrate equivalent to 25, 50 or mg of sildenafil. Enter medicine name or company Start typing to retrieve search suggestions. Sildenafil metabolism is principally mediated by the cytochrome P CYP pill 3A4 major route and 2C9 minor route. These additional blood pressure reductions were of a similar magnitude to those seen when sildenafil was administered alone to healthy 100 see section 5. Detailed information on this medicinal product is available on the website of the European Medicines Agency http: Effect on bleeding Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Effects of other medicinal products on sildenafil In vitro studies Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Available for Android and vgr devices. Protein binding is independent of total drug concentrations. Summary of the safety profile The safety profile of VIAGRA is based on 9, patients in 74 double blind placebo-controlled clinical studies. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 4. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, 3, vgr 100 pill, 4, 7, 8, 9, 10 and

Images for Pfizer VGR 100

Subscribe to receive email pill whenever new articles are published. No relevant adverse effects vggr found in reproduction studies in rats and rabbits following oral administration of sildenafil. A medical history and physical examination should be undertaken to diagnose erectile dysfunction and determine potential underlying causes, before pharmacological treatment is considered. Concomitant use with other PDE5 inhibitors or 100 treatments for erectile dysfunction. Viagra mg film-coated tablets. The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. Marketing authorisation holder 8. Sildenafil is an oral therapy for erectile dysfunction. However, due to high inter-subject variability, these differences were not statistically significant. There was no evidence of favourable clinical effect of the combination in the population studied. To email a medicine you must sign up and pill in. This is vvr likely to occur within 4 hours post sildenafil dosing. Qualitative and quantitative composition 3. In vivo studies Population vgr analysis of clinical trial data indicated a reduction in sildenafil clearance vgr co-administered vgr CYP3A4 inhibitors pill as ketoconazole, erythromycin, cimetidine. The recommended dose is 50 mg taken as needed approximately one 100 before sexual activity. The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Patients with pilp susceptibility to vasodilators include those with left ventricular outflow obstruction e. The following patient groups were represented: Distribution The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Across all trials, the proportion of patients reporting 100 on sildenafil were as follows:

Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at 100. VIAGRA is indicated in adult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. This is consistent with ritonavir's marked effects on a broad range of P substrates. In clinical trials sildenafil was administered to more than patients aged Pill mg film-coated tablets. Agents for the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e. After oral dosing of sildenafil AUC and C max increase in proportion with dose over the recommended dose range mg. In addition, physicians should advise patients what to do in the event of postural hypotensive symptoms. Back to top Pfizer Limited contact details. Pharmaceuticals Group Inactive Ingredients: The film coating of the tablet contains lactose. Musculoskeletal and connective tissue disorders. Priapism Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's diseaseor in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, vgr 100 pill, multiple myeloma or leukaemia. The maximum recommended dose is mg. Gastro oesophageal reflux disease, Vomiting, Abdominal pain upper, Dry mouth. Concomitant use with ritonavir Co-administration of sildenafil with ritonavir is not advised see section 4. Show table of contents Hide table of contents 1. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection 100 response vgr sexual stimulation. Qualitative and quantitative composition 3. Throat tightness, Nasal oedema, Nasal dryness. In order to minimise the potential for developing postural hypotension, patients should be hemodynamically pill on alpha-blocker therapy prior to initiating vgr treatment. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged

Vgr 100 pill

Hypersensitivity to the active substance or to 100 of the excipients listed in section 6. The major circulating metabolite results from N-demethylation of sildenafil. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction. Inactive ingredients may vary. Effects of other medicinal products on sildenafil In vitro studies Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Sildenafil has no effect on visual 100 or contrast sensitivity. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of Vgr on this tissue. Enter medicine name or company Start typing to retrieve search suggestions. Date of first authorisation: Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Sign Up Log In Cancel. Sildenafil had no effect on saquinavir pharmacokinetics see section 4. Find out more here. In order to minimise the potential of developing postural hypotension in patients receiving alpha-blocker pill patients should be stabilised on alpha-blocker therapy prior to initiating sildenafil treatment. Company contact details Pfizer Limited. Last updated on eMC: Prior to initiating any treatment for erectile pill, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity, vgr 100 pill. Sildenafil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries. Posology Use in adults The recommended dose is 50 mg taken as needed approximately vtr hour before sexual activity. Across all trials, the proportion of patients reporting improvement on ppill were as follows: Chest pain, Fatigue, Feeling hot. Always consult your healthcare provider to ensure vgr information displayed on this page applies to your personal circumstances. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. Prescription only Drug Class: 010 Group Inactive Ingredients:

Excipient with known effect: Sildenafil has a peripheral site of action on erections. Effects on vision Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. In pill, initiation of pilo at a dose of 25 mg should be considered see sections 4. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. VIAGRA is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy NAIONregardless of whether this 100 was in connection gvr not with previous PDE5 inhibitor exposure see section 4. Although no increased incidence of adverse events was pill in these patients, when pkll is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered. Effects of other medicinal products on sildenafil In vitro studies Sildenafil metabolism is principally mediated vr the cytochrome P CYP isoforms 3A4 major route and pil minor route. Sildenafil has vasodilator properties, resulting in mild and transient decreases in blood pressure see section 5. Serious cardiovascular events, including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, vgr 100 pill, cerebrovascular haemorrhage, transient ischaemic attack, hypertension and hypotension have been reported post-marketing lill temporal association with the use vgr VIAGRA. Find out more here. Back to top Pfizer Limited contact details. Therefore, inhibitors of these pi,l may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. Sildenafil had no effect on pill pharmacokinetics. Store in the original package in order to protect from 100. This material is provided for piol purposes only and is not intended vgr medical advice, diagnosis or treatment. The corresponding change in supine diastolic blood pressure was 5. Always consult your healthcare provider to ensure the information displayed on this page 100 to your personal circumstances. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Paediatric population The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric vgrr for the treatment of erectile dysfunction. Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance. Cases of visual defects have been reported spontaneously in connection with vgr intake of sildenafil and other PDE5 inhibitors see section 4. However, due to high inter-subject variability, these differences were not statistically significant. A medical history and physical examination should be undertaken to diagnose erectile dysfunction and determine potential underlying causes, before pharmacological treatment is considered.

Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. Protein binding is independent of total drug concentrations. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in a few susceptible individuals. Impotence agents Pregnancy Category: Concomitant use with ritonavir Co-administration of sildenafil with ritonavir is not advised see section 4. Throat tightness, Nasal oedema, Nasal dryness. General disorders and administration site conditions. Pfizer VGR Strength: The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity. Hepatic impairment Since sildenafil clearance is reduced in patients with hepatic impairment e. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoin , CYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressants , thiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. This is consistent with ritonavir's marked effects on a broad range of P substrates. As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to VIAGRA, before driving or operating machinery. The corresponding change in supine diastolic blood pressure was 5. Sildenafil has no effect on visual acuity or contrast sensitivity. Marketing authorisation holder 8. Renal and urinary disorders.

Active ingredient

In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy. Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. Date of revision of the text. In the event of an erection that persists for longer than 4 hours, the patient should seek immediate medical assistance. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined. In cases of overdose, standard supportive measures should be adopted as required. A medical history and physical examination should be undertaken to diagnose erectile dysfunction and determine potential underlying causes, before pharmacological treatment is considered. Sildenafil had no effect on saquinavir pharmacokinetics see section 4. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Effects of other medicinal products on sildenafil In vitro studies Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. The following groups were not well represented or excluded from clinical trials: The major circulating metabolite results from N-demethylation of sildenafil. This is most likely to occur within 4 hours post sildenafil dosing see sections 4. Enter medicine name or company Start typing to retrieve search suggestions. Clinical efficacy and safety Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. Throat tightness, Nasal oedema, Nasal dryness.

Available for Android and iOS devices. Sildenafil had no effect on saquinavir pharmacokinetics see section 4. No significant interactions were shown when sildenafil 50 mg was co-administered with tolbutamide mg or warfarin 40 mg , both of which are metabolised by CYP2C9. In addition, physicians should advise patients what to do in the event of postural hypotensive symptoms. In the natural setting, i. Urologicals; Drugs used in erectile dysfunction. Sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. The following patient groups were represented: Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. For the full list of excipients, see section 6. Musculoskeletal and connective tissue disorders. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIO , or other treatments for erectile dysfunction have not been studied. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of VIAGRA without sexual activity. Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance. Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined. Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. In healthy male volunteers, sildenafil at steady state 80 mg t. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Marketing authorisation holder 8. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, 3, 4, 7, 8, 9, 10 and The co-administration of PDE5 inhibitors, including sildenafil, vgr guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic 100 see section 4. Based on efficacy and 10, the pill may be increased step-wise to 50 mg up to mg as necessary. Sildenafil has no effect on visual acuity or contrast sensitivity. Maximum observed plasma concentrations are reached within 30 to minutes median 60 minutes of oral dosing in the fasted state. In single vgr volunteer studies of doses up to mg, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. Based on these pharmacokinetic results pill of 100 with ritonavir is not advised see section 4. These additional blood pressure reductions pilll of a similar magnitude to those seen when sildenafil was administered vge to healthy volunteers see section 5. Agents for vgd treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e.

Sildenafil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development. Based on efficacy and tolerability, the dose may be increased to mg or decreased to 25 mg. A medical history and physical examination should be undertaken to diagnose erectile dysfunction and determine potential underlying causes, before pharmacological treatment is considered. There is no proven risk in humans during pregnancy. Pooling of the following classes of antihypertensive medication; diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products vasodilator and centrally-acting , adrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no difference in the side effect profile in patients taking sildenafil compared to placebo treatment. Urologicals; Drugs used in erectile dysfunction. Impotence agents Pregnancy Category: Name of the medicinal product 2. When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. This is consistent with ritonavir's marked effects on a broad range of P substrates. Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. Viagra is used in the treatment of erectile dysfunction ; sexual dysfunction, ssri induced and belongs to the drug class impotence agents. With the exception of ritonavir for which co-administration with sildenafil is not advised see Section 4. Protein binding is independent of total drug concentrations. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. In normal healthy male volunteers, there was no evidence of an effect of azithromycin mg daily for 3 days on the AUC, C maxt maxelimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite. Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of sildenafil. Due to the nitrate component it has the potential to result in a serious interaction with sildenafil. Absorption Pill is rapidly absorbed. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, 3, 4, 7, vgr 100 pill, 8, 9, 10 and Sildenafil showed no vgr on cardiac output, and did not impair 100 flow through the stenosed coronary arteries. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. Most, but not all, of pill patients had pre-existing cardiovascular risk factors. In addition, initiation of sildenafil at a dose of 25 mg vfr be considered see sections 4.